Stoyanova Lab News

Exciting News: Dr. Tanya Stoyanova receives Department of Defense Exploration-Hypothesis Development Award

Exciting News: Dr. Tanya Stoyanova receives Department of Defense Exploration-Hypothesis Development Award

Dr. Tanya Stoyanova receives Department of Defense Exploration-Hypothesis Development Award

Dr. Tanya Stoyanova, associate professor of molecular and medical pharmacology and urology at the David Geffen School of Medicine at UCLA, was awarded an Exploration-Hypothesis Development Award from the Department of Defense to develop new approaches to detect and treat neuroendocrine prostate cancer, a highly aggressive subtype of prostate cancer known for its poor prognosis and limited therapeutic options.

The award will help support Stoyanova, a member of the UCLA Health Jonsson Comprehensive Cancer Center, and her team in testing blood levels of ubiquitin carboxy-terminal hydrolase L1 — a protein recently discovered by Stoyanova to be a novel promising molecular indicator and target for neuroendocrine prostate cancer — from patients suffering from this cancer. The team will then test the use of the protein as a blood biomarker to diagnose and track how patients respond to therapies, while also testing different new drugs that target the protein to see if they could be effective new treatment options.

“Prostate cancer is the second leading cause of cancer-associated mortality among men in the U.S. and affects active-duty military, veterans and their families,” said Stoyanova, also a member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA. “Our hope is that successful completion of this study will unveil new minimally invasive blood-based tests to diagnose and monitor responses to therapies for this highly aggressive subtype of prostate cancer, and reveal new treatment strategies for patients suffering from the disease.”

See Full Article at: https://www.uclahealth.org/news/release/dr-tanya-stoyanova-receives-department-defense-exploration

News UCLA
Welcome Donny Gunn, a senior animal technician, to the lab!

Welcome Donny Gunn, a senior animal technician, to the lab!

Welcome to Stoyanova lab, Donny!

News UCLA
Dr. Shiqin Liu presents her project “Shed Trop2 drives prostate cancer progression and Trop2 is a novel tissue prognostic biomarker and a candidate urinary marker for prostate cancer”

Dr. Shiqin Liu presents her project “Shed Trop2 drives prostate cancer progression and Trop2 is a novel tissue prognostic biomarker and a candidate urinary marker for prostate cancer”

Dr. Shiqin Liu presented her project “Shed Trop2 drives Prostate Cancer Progression and Trop2 is a novel Tissue Prognostic Biomarker and a candidate urinary marker for prostate cancer” at the 2024 AACR.

News UCLA
Dr. Alifiani Hartono presents her project “CDC7 is a targetable regulator of advanced prostate cancer”

Dr. Alifiani Hartono presents her project “CDC7 is a targetable regulator of advanced prostate cancer”

Dr. Alifiani Hartono presented her project CDC7 is a targetable regulator of advanced prostate cancer” for her poster session at the 2024 AACR.

News UCLA
Dr. Tanya Stoyanova gives a talk at 2024 AACR on “UCHL1 as a Molecular indicator and therapeutic target for neuroendocrine carcinomas”

Dr. Tanya Stoyanova gives a talk at 2024 AACR on “UCHL1 as a Molecular indicator and therapeutic target for neuroendocrine carcinomas”

Dr. Stoyanova gave a talk on a project “UCHL1 as a Molecular Indicator and Therapeutic Target for Neuroendocrine Carcinomas” at the 2024 AACR.

News UCLA
Nakea Pennant receives 2024 AACR Minority Scholar in Cancer Award

Nakea Pennant receives 2024 AACR Minority Scholar in Cancer Award

Nakea Pennant, a PhD candidate at Clark-Atlanta University and a participant in the 2023 Clark-Atlanta University-UCLA DMMP Summer Research Program, won the 2024 AACR Minority Scholar in Cancer Award with her project “CXCR4/CB2 Antagonizes CXCR4-mediated metastasis in Tumor Growth in-vivo”.

Congratulations, Nakea!

News UCLA
Exciting News: Dr. Shiqin (Laura) Liu is promoted to Assistant Adjunct Professor

Exciting News: Dr. Shiqin (Laura) Liu is promoted to Assistant Adjunct Professor

Dr. Shiqin Liu has been promoted to Assistant Adjunct Professor at the Department of Molecular and Medical Pharmacology at the University of California, Los Angeles!

Congratulations Laura!

News UCLA
Biofabrication of prostate cancer-like 3D models utilizing co-axial hydrogel spinning

Biofabrication of prostate cancer-like 3D models utilizing co-axial hydrogel spinning

Stoyanova lab is excited to share our new publication in Biofabrication on using Co-axial hydrogel spinning technology for facile biofabrication of 3D prostate cancer models, in collaboration with Dr. Utkan Demirci’s lab.

Congratulations!

Link to Publication: https://iopscience.iop.org/article/10.1088/1758-5090/ad2535

News UCLA
UCHL1 is a potential molecular indicator and therapeutic target for neuroendocrine carcinomas

UCHL1 is a potential molecular indicator and therapeutic target for neuroendocrine carcinomas

Stoyanova lab is excited to share our new publication on Cell Reports Medicine on revealing mechanisms of UCHL1 function in regulating the progression of neuroendocrine carcinomas and identifying UCHL1 as a therapeutic target and potential molecular indicator for diagnosing and monitoring treatment responses in these malignancies.

Congratulations!

Link to Publication: https://www.cell.com/cell-reports-medicine/pdf/S2666-3791(23)00610-9.pdf

News UCLA
High expression of Trop2 is associated with aggressive localized prostate cancer and is a candidate urinary biomarker

High expression of Trop2 is associated with aggressive localized prostate cancer and is a candidate urinary biomarker

Stoyanova lab is excited to share our new work on identifying Trop2 protein as a novel prognostic tissue biomarker and non-invasive urinary biomarker for prostate cancer.
Congratulations!

Link to Publication: https://www.nature.com/articles/s41598-023-50215-z

News UCLA