Dr. Stoyanova awarded R01 grant by the National Institutes of Health (NIH)/National Cancer Institute (NCI) for the project titled “Delineating the Role of GSTP1 in Advanced Prostate Cancer.”
Dr. Tanya Stoyanova, associate professor of molecular and medical pharmacology and urology at the David Geffen School of Medicine at UCLA, was awarded a $1.5 million grant from the National Cancer Institute to identify new treatment strategies for neuroendocrine prostate cancer, a highly aggressive form of the disease. Her project is titled “Delineating the Role of GSTP1 in Advanced Prostate Cancer,” and she will be investigating ways to utilize GSTP1, a membrane protein overexpressed in advanced prostate cancer cells, as a biomarker and a therapeutic target for early detection and targeted therapy.
Currently, the first line of treatment for many men with advanced metastatic prostate cancer is hormone therapy. Although the treatment can work for some, the cancer often comes back in a more aggressive form and becomes resistant to hormone therapy. Neuroendocrine prostate cancer is a highly aggressive subtype of prostate cancer that increases in incidence after development of hormone therapy resistance.
The grant will help support Stoyanova and her team identify new molecular mechanisms underlying the development of neuroendocrine prostate cancer, investigate what role a detoxification enzyme may play in contributing to the disease, and test new agents — on their own and in combination — to see if they can be effective treatments for the hard-to-treat cancer.
“With this study, we hope to set the foundation for clinical trials with new therapeutic interventions and combinations of therapeutic agents to combat metastatic neuroendocrine prostate cancer,” said Stoyanova, a member of the UCLA Jonsson Comprehensive Cancer Center and the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA.
To check out the full article: https://www.uclahealth.org/news/dr-tanya-stoyanova-awarded-15-million-uncover-new-ways-treat